best shot Dems have at doing anything is finding a way to keep the house. Odds are they will pick up 2-3 senate seats in PA, WI or North Carolina. They may lose 1 seat but odds are they will keep the senate. If Dems find a way to win 2-3 senate seats Manchin and Sinema will be irrelevant. Hardest part will be keeping the house because of all the gerrymandering and the new census will favor Republicans.